An approach for nanopore-based DNA sequencing using characteristic transverse differential conductance has been developed by HE Yuhui, a postdoc researcher in Institute of Microelectronics (IME) of Chinese Academy of Sciences.

According to HE, molecular dynamics and electron transport simulations show that the transverse differential conductance during the translocation of DNA through the nanopore is distinguishable enough for the detection of the base sequence and can withstand electrical noise caused by DNA structure fluctuation. And the findings demonstrate several advantages of the transverse conductance approach including lower noises, higher accuracy, and higher efficiency, which may lead to important applications in rapid genome sequencing.
HE now works at the Micro-Fabrication and Nano technology Department under IME, and his findings has been published as the cover article titled “Differential conductance as a promising approach for rapid DNA sequencing with nanopore-embedded electrodes” in Applied Physics Letters 97, 043701 (2010).